Ca2+ currents in compensated hypertrophy and heart failure
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چکیده
منابع مشابه
Ca2+ currents in compensated hypertrophy and heart failure.
Transmembrane voltage-gated Ca2+ channels play a central role in the development and control of heart contractility which is modulated by the concentration of free cytosolic calcium ions (Ca2+). Ca2+ channels are closed at the normal membrane resting potential of cardiac cells. During the fast upstroke of the action potential (AP), they are gated into an open state by membrane depolarisation an...
متن کاملAnalysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure.
BACKGROUND Congestive heart failure (CHF) is associated with a change in cardiac energy metabolism. However, the mechanism by which this change is induced and causes the progression of CHF is unclear. METHODS AND RESULTS We analyzed the cardiac energy metabolism of Dahl salt-sensitive rats fed a high-salt diet, which showed a distinct transition from compensated left ventricular hypertrophy t...
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Heart failure presents a number of difficulties. Its very definition has proved taxing, and the clinical diagnosis is frequently incorrect. Patients with objective abnormalities of left ventricular function are not infrequently asymptomatic, hence treatment is often delayed. Even when a firm diagnosis is secured, only a minority of patients receive optimal medical treatment. Of concern is the i...
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In cardiac and skeletal muscle, the sarcoplasmic reticulum (SR) plays a central role in the contraction relaxation cycle of the muscle by virtue of its ability to regulate the intracellular free Ca'+ concentration [Ca'+],. Ca'+ release from the SR increases [Ca'+] (10`mol/L), thus inducing contraction, whereas Ca2` uptake by the SR reduces [Ca'+] (=10-7 mol/L), producing muscle relaxation. In c...
متن کاملDecreased Ca2+ extrusion via Na+/Ca2+ exchange in epicardial left ventricular myocytes during compensated hypertrophy.
Hypertension-induced cardiac hypertrophy alters the amplitude and time course of the systolic Ca2+ transient of subepicardial and subendocardial ventricular myocytes. The present study was designed to elucidate the mechanisms underlying these changes. Myocytes were isolated from the left ventricular subepicardium and subendocardium of 20-wk-old spontaneously hypertensive rats (SHR) and age-matc...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1998
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(97)00273-3